Endocrine Abstracts

The V600E mutation of BRAF oncogene is one of the most frequent genetic events in thyroid cancer, particularly in papillary thyroid carcinomas (PTC) and in some anaplastic carcinomas that derive from preexisting PTC. It has been associated with advanced clinical stages, extrathyroidal extension, and a high risk of recurrences, particularly those that have lost the ability to accumulate iodide, a property mediated by the sodium iodide symporter (NIS).Our ...